A population-based case-control study was conducted between 1988 and 1995 in the San Francisco Bay Area of California to determine risk factors for non-Hodgkin's lymphoma.
Participants completed in-person interviews, and blood was drawn to test for viruses and lymphocyte subsets.
This report includes data for 1,281 cases and 2,095 controls.
In multivariate analyses, the factors associated with a decreased risk for non-Hodgkin's lymphoma were allergy to plants, bee and wasp stings, five or more vaccinations, drugs to lower blood cholesterol, nonsteroidal anti-inflammatory drugs, total number of sexual partners, and lifetime marijuana use, whereas an increased risk was associated with cimetidine and other histamine H2-receptor antagonists, splenectomy, gonorrhea, and body mass index.
Unique to sex-specific models was an increased risk for endocrine gland disorders among women and for polio among men.
Median CD3, CD4, CD8, CD20, and lymphocyte counts for non-Hodgkin's lymphoma patients were significantly lower than those for controls.
These results implicate environmental factors that may influence the early stages of lymphomagenesis by stimulating the immune system.
Antigen-driven B cells that accumulate to form lymphoma may be suppressed by immunologic stresses such as exposure to an increased number of sexual partners and to certain medications. (...)
Mots-clés Pascal : Lymphome non hodgkinien, Hétérosexualité, Mode de vie, Immunité, Virus, Allergie, Exposition, Produit chimique, Exposition professionnelle, Epidémiologie, Facteur risque, Homme, Etude cas témoin, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Non Hodgkin lymphoma, Heterosexuality, Life style, Immunity, Virus, Allergy, Exposure, Chemical product, Occupational exposure, Epidemiology, Risk factor, Human, Case control study, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0430650
Code Inist : 002B19B. Création : 22/03/2000.