Trends in cervical cancer incidence following the introduction of screening have mostly been studied using cross-sectional data and not analysed separately for squamous cell cancer and adenocarcinomas.
Using Swedish nationwide data on incidence and mortality, we analysed trends during more than 3 decades and fitted Poisson-based age-period-cohort models, and also investigated whether screening has reduced the incidence of adenocarcinomas of the cervix.
The incidence of reported cancer in situ increased rapidly during 1958-1967.
Incidence rates of squamous cell cancer, fairly stable before 1968, decreased thereafter by 4-6% yearly in women aged 40-64, with a much smaller magnitude in younger and older women.
An age-cohort model indicated a stable 70-75% reduction in incidence for women born 1940 and later compared with those born around 1923.
The incidence of adenocarcinomas doubled during the 35-year study period.
The mortality rate increased by 3.6% before 1968 and decreased by 4.0% yearly thereafter.
Although a combination of organized and opportunistic screening can reduce the incidence of squamous cell cancer substantially, the incidence of adenocarcinomas appears uninfluenced by screening.
Mots-clés Pascal : Adénocarcinome, Col utérus, Incidence, Frottis cervical, Dépistage, Mortalité, Epidémiologie, Suède, Europe, Age, Echelle temps, Etude cohorte, Homme, Tumeur maligne, Col utérus pathologie, Appareil génital femelle pathologie, Anatomopathologie
Mots-clés Pascal anglais : Adenocarcinoma, Uterine cervix, Incidence, Cervical smear, Medical screening, Mortality, Epidemiology, Sweden, Europe, Age, Time scale, Cohort study, Human, Malignant tumor, Uterine cervix diseases, Female genital diseases, Pathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0429595
Code Inist : 002B20C02. Création : 22/03/2000.