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  1. Biological interpretation of relative risk.

    Article - En anglais

    There is widespread interest in assessing the clinical importance of a study result.

    This goal is impeded, however, by a lack of clarity about the biological interpretability of epidemiological effect measures, such as the relative risk.

    A relative risk is often interpreted merely as a measure of some vague statistical association, without a view toward a biological effect as an object of measurement.

    Not infrequently, if it is not statistically significant, the relative risk estimate is ignored completely.

    A key to biological interpretation is appreciating the theoretical framework stipulating that outcome rates derived from 2 comparison groups actually represent measures of different effects in the same population.

    For instance, by using a placebo group to estimate the number of background cases that occurred in the treatment group, an estimate of the number of excess cases that occurred as a result of treatment can be made.

    This kind of biological entity can be derived from a relative risk, and can be more easily evaluated as to its clinical importance than a statistical association or a statement about statistical significance.

    Interpretation then becomes a more directed task, with a focus on the validity of certain ancillary hypotheses upon which biological interpretability rests.

    Mots-clés Pascal : Article synthèse, Interprétation, Risque, Analyse risque, Effet biologique, Epidémiologie, Homme, Essai clinique phase III

    Mots-clés Pascal anglais : Review, Interpretation, Risk, Risk analysis, Biological effect, Epidemiology, Human, Phase III trial

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0429555

    Code Inist : 002B30A01A2. Création : 22/03/2000.