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  1. Dose-effect relationship between overdose mortality and prescribed methadone dosage in low-threshold maintenance programs.

    Article - En anglais

    The present study evaluates the effectiveness of low-threshold methadone maintenance in reducing overdose mortality.

    In a prospective cohort study conducted in Amsterdam, 498 Dutch injecting drug users (IDU) provided 1,969 person years of follow-up (1989-1995).

    Forty-four IDU died in this period, 15 due to illicit drug overdose.

    Compared to IDU not in maintenance, the adjusted relative risk for overdose mortality among those receiving 5-50 mg, 55-70 mg, and 75+mg were 0.35,0.13, and 0.11, respectively (p<. 05).

    Also current injection use and HIV-seropositivity were independent predictors for overdose mortality.

    Whereas previous studies indicated effectiveness of methadone-assisted detoxification and high-dose maintenance programs in reducing mortality, the present study findings suggest that low-threshold maintenance programs also reduce overdose mortality, with higher dosages being most protective.

    Mots-clés Pascal : Toxicomanie, Opiacés, Chimiothérapie, Méthadone, Analgésique narcotique, Traitement substitutif, Posologie, Prescription médicale, Prévention, Mortalité, Overdose, Etude longitudinale, Epidémiologie, Facteur risque, Santé mentale, Pays Bas, Europe, Homme

    Mots-clés Pascal anglais : Drug addiction, Opiates, Chemotherapy, Methadone, Narcotic analgesic, Replacement therapy, Posology, Medical prescription, Prevention, Mortality, Overdose, Follow up study, Epidemiology, Risk factor, Mental health, Netherlands, Europe, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0429489

    Code Inist : 002B03D. Création : 22/03/2000.