Findings have been inconsistent on effects of adolescent body size and adult weight gain on risk of breast cancer in young women.
These relations were examined in a population-based case control study of 1590 women less than 45 years of age newly diagnosed with breast cancer during 1990-1992 in three areas of the US and an age-matched control group of 1390 women.
Height and weight were measured at interview and participants asked to recall information about earlier body size.
Logistic regression was used to estimate the relative risk of breast cancer adjusted for other risk factors.
Women who were either much heavier or lighter than average in adolescence or at age 20 were at reduced risk.
Weight gain after age 20 resulted in reduced risk, but the effect was confined to early-stage and, more specifically, lower grade breast cancer.
Neither the risk reduction nor the variation by breast cancer stage or grade was explained by the method of cancer detection or by prior mammography history.
These findings suggest that relations between breast cancer risk in young women and body weight at different ages is complex and that the risk reduction with adult weight gain is confined to less aggressive cancers.
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Facteur risque, Epidémiologie, Taille corporelle, Prise poids, Type histologique, Stade clinique, Préménopause, Puberté, Etats Unis, Amérique du Nord, Amérique, Etude cas témoin, Femelle, Adulte jeune, Homme, Glande mammaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Risk factor, Epidemiology, Body size, Weight gain, Histological type, Clinical stage, Premenopause, Puberty, United States, North America, America, Case control study, Female, Young adult, Human, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0429088
Code Inist : 002B20E02. Création : 22/03/2000.