Occupational asthma (OA) can be a debilitating disease even when removal from the workplace is achieved.
Today, the « gold standard » in the assessment of OA is the bronchial provocation test (BPT).
Induced sputum is a non-invasive method of exploring airway inflammation which can provide additional information about such challenges and thus could be applied in OA diagnosis and monitoring.
We report the study carried out in a grain worker sensitized to Lepidoglyphus destructor (Ld), who suffered from mild asthma at the workplace.
Skin prick test and specific serum IgE were measured.
Ld-BPT was performed, and the changes in eosinophil rates, and ECP and tryptase levels in induced sputum were studied 30 min and 18 h after Ld-BPT.
We also determined the changes in nonspecific bronchial hyperresponsiveness (NSBH), given as PD20 values.
To assess the specificity of the changes, we also carried out sputum induction and methacholine challenge after barley-BPT.
An isolated immediate response was obtained with Ld-BPT, while barley-BPT was negative.
Induced sputum showed higher tryptase levels 30 min after Ld-BPT, and higher eosinophil and epithelial cell percentages and ECP levels 18 h after Ld-BPT.
There was also a decrease in methacholine PD20 values after Ld-BPT.
Those changes were not observed after barley-BPT. (...)
Mots-clés Pascal : Asthme, Allergie, Etiologie, Allergène, Pneumallergène, Exposition professionnelle, Grain, Céréale, Silo agricole, Etude cas, Mâle, Adulte, Homme, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie, Médecine travail, Lepidoglyphus destructor, Acarien
Mots-clés Pascal anglais : Asthma, Allergy, Etiology, Allergen, Aeroallergen, Occupational exposure, Grains, Cereal, Farm silo, Case study, Male, Adult, Human, Respiratory disease, Obstructive pulmonary disease, Immunopathology, Occupational medicine, Lepidoglyphus destructor, Mite
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0428793
Code Inist : 002B06C02. Création : 22/03/2000.