Background There is considerable evidence that insulin resistance with compensatory hyperinsulinaemia is an early and modifiable defect in the pathogenesis of non-insulin dependent diabetes (NIDDM).
Current data, however, are largely based on studies that have used insulin assays which cross-react with proinsulin and other insulin precursors.
Using a specific assay, we have addressed the hypothesis that an elevation of serum true insulin concentration, reflecting insulin resistance, is an early event in the pathogenesis of NIDDM.
Methods We have used a prospective cohort study design in which a group of 5550 non-diabetic men aged 40-59 years, from 18 British towns, have been followed for incident cases of physician-diagnosed NIDDM for an average of period of 14.8 years (range 13.5-15 years).
We have estimated the incidence of physician-diagnosed NIDDM by quintile of non-fasting serum true insulin concentration at entry into the study.
Results There were 168 cases of clinically diagnosed NIDDM among the group of 5550 men during follow-up.
Mean serum insulin at entry (geometric mean and 95% range, adjusted for time of sampling) was significantly higher in men who subsequently developed NIDDM than in the rest of the cohort, 19.5 mU/l (4.3-88.2) versus 12.2 mU/l (2.7-54.0), P<0.0001. (...)
Mots-clés Pascal : Diabète non insulinodépendant, Homme, Mâle, Dépistage, Etude cohorte, Etude longitudinale, Etude multicentrique, Facteur prédictif, Hyperinsulinémie, Analyse biochimique, Royaume Uni, Europe, Epidémiologie, Incidence, Recommandation, Endocrinopathie
Mots-clés Pascal anglais : Non insulin dependent diabetes, Human, Male, Medical screening, Cohort study, Follow up study, Multicenter study, Predictive factor, Hyperinsulinemia, Biochemical analysis, United Kingdom, Europe, Epidemiology, Incidence, Recommendation, Endocrinopathy
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0425943
Code Inist : 002B21E01A. Création : 22/03/2000.