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  1. Systemic lupus erythematosus in three ethnic groups. IV. Factors associated with self-reported functional outcome in a large cohort study.

    Article - En anglais

    Objective

    To identify features of systemic lupus erythematosus (SLE) associated with poor functional outcome as measured by the 36-item Medical Outcomes Study Short Form 36 Health Survey (SF-36).

    Methods

    Two hundred twenty-four patients with early SLE (70 Hispanic. 83 African American, and 71 white) enrolled in a longitudinal study of outcomes were evaluated at study entry.

    The 8 composite scales and 2 summary measures (physical and mental) of the SF-36 were the dependent variables.

    Independent variables-1) sociodemographic, 2) clinical features, 3) immunologic, 4) global scores, and 5) behavioral/cultural were examined for each of the scales and summary measures and for each ethnic group.

    Significant variables in these analyses were then used to construct models to determine their association with each of the scales and the 2 summary measures for the entire population and the 3 ethnic groups.

    Results

    Self-reported physical and mental functioning were most consistently associated with abnormal illness-related behaviors, helplessness, fatigue, and pain at study entry.

    Helplessness was more strongly associated with functioning in the Hispanics than in the African American or white patients.

    Pain was strongly associated with physical but not mental health.

    The models were quite robust, accounting for 41% to 68% of the variance for the two summary measures. (...)

    Mots-clés Pascal : Lupus érythémateux, Disséminé, Symptomatologie, Epidémiologie, Facteur risque, Ethnie, Pronostic, Homme, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie

    Mots-clés Pascal anglais : Lupus erythematosus, Disseminated, Symptomatology, Epidemiology, Risk factor, Ethnic group, Prognosis, Human, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0425873

    Code Inist : 002B07. Création : 22/03/2000.