Cost-effectiveness of malaria control in sub-Saharan Africa.
Background Information on the cost-effectiveness of malaria control is needed for the WHO Roll Back Malaria campaign, but is sparse.
We used mathematical models to calculate cost-effectiveness ratios for the main prevention and treatment interventions in sub-Saharan Africa.
Methods We analysed interventions to prevent malaria in childhood (insecticide-treated nets, residual spraying of houses, and chemoprophylaxis) and pregnancy (chloroquine chemoprophylaxis and sulfadoxine-pyrimethamine intermittent treatment), and to improve malaria treatment (improved compliance, improved availability of second-line and third-line drugs, and changes in first-line drug).
We developed models that included probabilistic sensitivity analysis to calculate ranges for the cost per disability-adjusted life year (DALY) averted for each intervention in three economic strata.
Data were obtained from published and unpublished sources, and consultations with researchers and programme managers.
Findings In a very-low-income country, for insecticide treatment of existing nets, the cost-effectiveness range was US$4-10 per DALY averted ; for provision of nets and insecticide treatment $19-85 ; for residual spraying (two rounds per year) $32-58 ; for chemoprophylaxis for children $3-12 (assuming an existing delivery system) ; for intermittent treatment of pregnant women $4-29 ; and for improvement in case management $1-8. (...)
Mots-clés Pascal : Paludisme, Protozoose, Parasitose, Infection, Plasmodium, Apicomplexa, Protozoa, Analyse coût efficacité, Economie santé, Traitement, Prévention, Enfant, Homme, Afrique subsaharienne, Afrique
Mots-clés Pascal anglais : Malaria, Protozoal disease, Parasitosis, Infection, Plasmodium, Apicomplexa, Protozoa, Cost efficiency analysis, Health economy, Treatment, Prevention, Child, Human, Sub-Saharan Africa, Africa
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0425859
Code Inist : 002B05E02B4. Création : 22/03/2000.