Background Orthotopic liver transplantation (OLT) is widely used to treat patients with end-stage liver disease.
However, data on the cost of the procedure are fragmentary.
We evaluated the costs, as calculated from resource use, and outcomes of OLT in adults, from registration on the transplant waiting list to the end of the 1st-year of follow-up after the transplant.
Two parallel cohort studies were conducted from 1994 to 95.
All patients ages 18 years and older, on the waiting list (n=33) according to national criteria or having undergone transplants (n=38) were followed for 1 year or until either the transplant (waiting list cohort) or death (waiting list and transplantation cohorts).
Eighty percent of the patients undergoing transplants were alive after 1 year, and no patient died while on the waiting list.
However, the estimated cost of the procedure was high : more than £55,000 for the 1st year after OLT, to be added to £5,500 for evaluation and further costs motivated by the planned transplant during an average 6.5 months on the waiting list.
Age over 40 and a baseline Child-Pugh score of 10 and over were predictive of high costs.
The proportion of costs associated with immunosuppressive therapy and rejection were very high. (...)
Mots-clés Pascal : Homotransplantation, Foie, Coût, Pronostic, Homme, Etude cohorte, Insuffisance hépatique, Terminal, Traitement, Transplantation, Chirurgie, Foie pathologie, Appareil digestif pathologie, Economie santé
Mots-clés Pascal anglais : Homotransplantation, Liver, Costs, Prognosis, Human, Cohort study, Liver failure, Terminal, Treatment, Transplantation, Surgery, Hepatic disease, Digestive diseases, Health economy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0425557
Code Inist : 002B25G03. Création : 22/03/2000.