The prevalence and distribution of extra-articular manifestations of rheumatoid arthritis (ExRA) and associated mortality were studied retrospectively in a cohort of RA patients admitted to University Hospital, Malmö, Sweden, during the period 1990-94.
Of 489 patients who fulfilled the 1987 ACR criteria for RA, 37 manifested onset of ExRA, predominantly serositis and cutaneous vasculitis, during the period, corresponding to a cumulative incidence of 7.9%. The occurrence of ExRA was independent of disease stage.
Among patients with ExRA, 1 death/4.3 person-years at risk (pyr) occurred, as compared with I death/11.4 pyr in the non-ExRA subgroup.
The age-and sex-adjusted mortality rate ratio was 2.49 (95% confidence interval 1.43-4.03).
The major cause of death among ExRA cases was heart disease, which occurred in 9/13 cases (69%) in comparison to the expected 2.4 cases.
In this series, serositis and cutaneous vasculitis were predominant extra-articular manifestations of RA ; and mortality was greater in the ExRA than in the non-ExRA subgroup, perhaps due to a high frequency of associated heart disease.
Mots-clés Pascal : Polyarthrite rhumatoïde, Symptomatologie, Association morbide, Epidémiologie, Incidence, Prévalence, Polyarthrite rhumatoïde Felty, Mortalité, Homme, Vascularite, Inflammation, Pleurésie, Péricardite, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Cardiopathie, Péricarde pathologie, Manifestation extraarticulaire
Mots-clés Pascal anglais : Rheumatoid arthritis, Symptomatology, Concomitant disease, Epidemiology, Incidence, Prevalence, Felty syndrome, Mortality, Human, Vasculitis, Inflammation, Pleurisy, Pericarditis, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease, Cardiovascular disease, Vascular disease, Heart disease, Pericardial disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0425517
Code Inist : 002B15D. Création : 22/03/2000.