logo BDSP

Base documentaire

Fermeture du portail BDSP le 1er juillet 2019. En savoir plus...

  1. Prevalence of protein-energy malnutrition at diagnosis in children with acute lymphoblastic leukemia.

    Article - En anglais


    The purpose of the present study was to test the hypothesis that protein-energy undernutrition is common in patients with acute lymphoblastic leukemia at diagnosis.

    Previous studies have failed to establish whether undernutrition is a common feature at diagnosis.


    Body mass index (BMI, weight/height2), expressed as a standard deviation score (SDS) relative to contemporary United Kingdom reference data, was used as the index of nutritional status.

    The index was calculated in a national cohort of standard-risk patients (n=1019) treated in the same protocol in the United Kingdom.


    Prevalence of undernutrition (defined as BMI SDS<-2.0) exceeded expected frequencies in boys (7.6%) and girls (6.7%). These differences were statistically significant (p<0.001), with a 95% confidence interval for the prevalence of undernutrition of 5.8% to 9.0%. Conclusions : Undernutrition is relatively common in patients with newly diagnosed acute lymphoblastic leukemia, with a threefold excess of patients below the cutoff used to define undernutrition.

    Screening for undernutrition at diagnosis of acute lymphoblastic leukemia is indicated, and the BMI SDS is a simple index of nutritional status that could be readily calculated using measurements routinely made at diagnosis.

    The same simple screening technique could also be used clinically to detect and manage or prevent overnutrition (obesity), which is common in these patients after diagnosis.

    Mots-clés Pascal : Leucémie lymphoblastique, Prévalence, Association, Malnutrition, Protéine, Energie, Indice masse corporelle, Diagnostic, Dépistage, Résultat, Enfant, Homme, Royaume Uni, Europe, Aigu, Hémopathie maligne, Lymphoprolifératif syndrome, Trouble nutrition, Métabolisme, Prévention, Organisation santé

    Mots-clés Pascal anglais : Acute lymphocytic leukemia, Prevalence, Association, Malnutrition, Protein, Energy, Body mass index, Diagnosis, Medical screening, Result, Child, Human, United Kingdom, Europe, Acute, Malignant hemopathy, Lymphoproliferative syndrome, Nutrition disorder, Metabolism, Prevention, Public health organization

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0424914

    Code Inist : 002B19B. Création : 22/03/2000.

Fermeture du portail BDSP le 1er juillet 2019

Nous avons le regret de vous informer de la fermeture du portail BDSP le 1er juillet 2019. Du 1er janvier au 30 juin 2019, le site et ses services resteront accessibles mais ne seront plus alimentés, ni mis à jour. En savoir plus...