In spite of the accumulating evidence of an increased prevalence of osteopenia and osteoporosis in patients with inflammatory bowel diseases (IBD), the time course of bone loss is not well described, and there is little knowledge about factors indicating an increased risk of rapid bone loss.
We conducted a follow-up study in 80 IBD patients (45 men and 25 premenopausal and 10 postmenopausal women), 19 with ulcerative colitis and 61 with Crohn disease, with a mean follow-up time of 568 ± 60 days, to assess bone loss, risk factors of rapid bone loss, and value of bone markers to predict bone loss.
Bone mineral density was measured by dual-energy X-ray absorptiometry, bone formation by bone alkaline phosphatase (BAP), and bone resorption by N-terminal telopeptide of type-I collagen (NTX) and free deoxypyridinoline (DPD).
Bone density changes per year were 0.46% ± 3% at the spine, 0.06% ± 5.1% at the femoral neck, - 1.1% ± 7.7% at the triangle of Ward, and - 0.52% ± 1.86% at total body level.
Type and duration of disease, sex, age, and level of NTX, DPD, and BAP at base line did not show significant differences between patients who lost and those who did not lose bone mass.
Bone loss was significantly higher in patients with (n=28) than in those without steroids (n=52) at the femoral neck and Ward triangle but not at the spine and total body. (...)
Mots-clés Pascal : Ostéoporose, Association, Complication, Rectocolite ulcérohémorragique, Entérite Crohn, Analyse biochimique, Masse osseuse, Perte, Métabolisme, Etude longitudinale, Article synthèse, Marqueur biologique, Facteur prédictif, Homme, Système ostéoarticulaire pathologie, Ostéopathie, Appareil digestif pathologie, Intestin pathologie, Maladie inflammatoire
Mots-clés Pascal anglais : Osteoporosis, Association, Complication, Ulcerative colitis, Crohn disease, Biochemical analysis, Bone mass, Loss, Metabolism, Follow up study, Review, Biological marker, Predictive factor, Human, Diseases of the osteoarticular system, Bone disease, Digestive diseases, Intestinal disease, Inflammatory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0424332
Code Inist : 002B24O08. Création : 22/03/2000.