Background Individuals with asthma are more atopic than the general population, but few reports have quantified this association, i.e. the proportion of asthma in the community due to specific immunoresponse.
We aimed to determine the population attributable risk of asthma in the community due to atopy, and the quantity and quality of specific immunoresponses to common aeroallergens involved.
Methods We used data from a cross-sectional study in a random sample of the general Spanish population, 20-44 years old, from five areas.
In all, 1816 participants were given a symptoms questionnaire, a methacholine challenge and were assessed for atopy.
Bronchial responsiveness (BR) was defined as a >=20% fall in forced expiratory volume in one second (FEV1) after methacholine.
Asthma was defined as symptomatic bronchial responsiveness.
Atopy was assessed by measuring serum specific IgE or skin tests for sensitivity to Alternaria, birch, cat, Cladosporium, Dermatophagoides pteronyssinus, olive, Parietaria, ragweed or timothy grass.
Results Sensitivity to any of the individual allergens tested significantly increased the risk of being asthmatic, at least twofold compared to non-atopic individuals.
The population attributable risk of atopy in explaining asthma is 41.97% (95% Cl : 29.2-60.3) when adjusting for area of residence, age, sex, and smoking. (...)
Mots-clés Pascal : Asthme, Homme, Facteur risque, Atopie, Questionnaire, Espagne, Europe, Epidémiologie, Prévalence, Exploration immunologique, Test cutané, Hyperréactivité, VEMS, Pneumallergène, Spirométrie, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie, Allergie
Mots-clés Pascal anglais : Asthma, Human, Risk factor, Atopy, Questionnaire, Spain, Europe, Epidemiology, Prevalence, Immunological investigation, Skin test, Hyperreactivity, Maximal expiratory volume per second, Aeroallergen, Spirometry, Respiratory disease, Obstructive pulmonary disease, Immunopathology, Allergy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0423737
Code Inist : 002B11B. Création : 22/03/2000.