Interactions of familial and hormonal risk factors for large bowel cancer in women.
Background Family history of colorectal cancer has been consistently associated with an increased personal risk of this disease.
Since evidence suggests that hormones are related to colon cancer risk in women, the effect of family history on large bowel incidence may be modified according to endogenous and exogenous hormone levels.
Methods We analysed data from a population-based case-control study of female colorectal cancer to evaluate family history and cancer risk.
Cases (n=702) were female residents of Wisconsin with a new diagnosis of colorectal cancer, identified through a statewide tumour registry.
Controls (n=2274) were randomly selected from lists of licensed drivers and from rosters of Medicare beneficiaries.
All relative risks (RR) were adjusted for age, body mass index, smoking and alcohol history, education, and use of hormone replacement therapy.
Results Compared with women who reported no history of cancer in a first degree relative, women with a family history had an RR of 2.07 (95% confidence interval [CI] : 1.60-2.68), Regardless of which parent was affected, risks were increased about twofold, while sibling history was associated with about a 50% increase in risk.
Risk was greater if more than one family member was affected (RR 3.65,95% CI : 1.81-7.37).
The association between family history and risk was stronger for colon cancer than for rectal cancer. (...)
Mots-clés Pascal : Tumeur maligne, Côlon, Rectum, Homme, Femelle, Facteur risque, Etude familiale, Traitement substitutif, Parent, Oestroprogestatif, Etats Unis, Amérique du Nord, Amérique, Epidémiologie, Evaluation, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie
Mots-clés Pascal anglais : Malignant tumor, Colon, Rectum, Human, Female, Risk factor, Family study, Replacement therapy, Parent, Estroprogestagen, United States, North America, America, Epidemiology, Evaluation, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0423366
Code Inist : 002B13B01. Création : 22/03/2000.