To investigate the effects of polycyclic aromatic hydrocarbons (PAHs) on the human immune system, analyses were performed on T-cell subsets (CD4+CD8+), B-cells (CD19+), serum immunoglobulin levels (IgG, IgM, IgA) and white blood cell percentages of 16 male workers who were employed in road paving operations and compared to 12 unexposed male controls.
PAH exposure was assessed using urinary 1-hydroxy-pyrene (I-OHP) levels and was found to be significantly higher in workers than in the controls.
While the CD4+cell percentage and the CD4+/CD8+ratio were significantly higher in the PAH-exposed group, the percentages of CD8+and CD19+cells were unchanged.
There was also a significant enhancement in serum IgG levels and the percentage of monocytes in the workers compared to the control group.
These data suggest that chronic exposure to PAHs may affect some immune functions in humans.
Mots-clés Pascal : Composé aromatique polycyclique, Hydrocarbure, Asphalte, Exposition professionnelle, Médecine travail, Homme, Toxicité, Réponse immune, Système immunitaire, Chronique, Industrie construction, Bitume, Route, Immunopathologie
Mots-clés Pascal anglais : Polycyclic aromatic compound, Hydrocarbon, Asphalt, Occupational exposure, Occupational medicine, Human, Toxicity, Immune response, Immune system, Chronic, Construction industry, Bitumen, Highway, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0421284
Code Inist : 002B03L06. Création : 22/03/2000.