Prognostic factors relating to survival in uterine endometrioid carcinoma.
Epidemiologic and clinicohistopathologic prognostic factors of uterine endometrioid carcinomas were analyzed.
The association of estrogen related factors, focused on adenomyosis in the prognosis of endometrioid carcinomas was also examined.
Risk factors of surgically treated 286 patients with endometrioid carcinoma (Stage I-III) were statistically analyzed.
Overall a recurrence-free 5-year survival rate was 81% (Stage I, 94%, Stage II, 71% and Stage III, 40%). Significant prognostic factors were lymph node metastases (P=0.0035) and serosal/parametrial invasion (P=0.014) by multivariate analysis.
Endometrioid carcinomas with co-existing adenomyosis tend to be associated with endometrial hyperplasia (P=0.04, Fisher's exact test), diagnosed in less invasive status (myometrial invasion, P=0.004 and serosal/parametrial invasion, P=0.006) and therefore have a favorable prognosis (P=0.01, log rank test).
A favorable prognosis of endometrioid carcinomas with co-existing estrogen related factors (adenomyosis and endometrial hyperplasia) was suggested.
Mots-clés Pascal : Carcinome, Endomètre, Survie, Indicateur, Epidémiologie, Pronostic, Prédicteur, Facteur risque, Homme, Femelle, Japon, Asie, Tumeur maligne, Appareil génital femelle pathologie, Utérus pathologie
Mots-clés Pascal anglais : Carcinoma, Endometrium, Survival, Indicator, Epidemiology, Prognosis, Predictor, Risk factor, Human, Female, Japan, Asia, Malignant tumor, Female genital diseases, Uterine diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0419082
Code Inist : 002B20C02. Création : 22/03/2000.