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  1. Glutathione transferase alpha as a marker for tubular damage after trichloroethylene exposure.

    Article - En anglais

    To investigate possible persistent nephrotoxic effects of trichloroethylene (TRI), a retrospective study was carried out on 39 workers exposed to high levels of TRI from 1956 to 1975.

    Total protein levels in urine, as well as serum and urine creatinine and serum urea were unchanged in comparison with the control.

    Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) was applied to differentiate between tubular and/or glomerular dysfunction.

    Urinary excretion of alpha-1-microglobulin and glutathione transferase (GST) alpha, as markers of proximal tubular damage, were correlated with the SDS-PAGE patterns of urinary proteins both in the TRI exposed and the control group.

    GST alpha was found in elevated concentrations in the urine of the TRI-exposed workers.

    No increase of urinary GST alpha was observed in the control group, even when alpha-l-microglobulin was elevated as a result of non-toxic damage.

    Both in the control and exposed groups, GST pi, a marker of distal tubular damage, was in the normal range.

    The results show that chronic exposure to high doses of TRI causes persistent changes to the proximal tubular system of the kidney and that GST alpha excretion into the urine is a marker well suited for quantitation of the extent of renal damage.

    Mots-clés Pascal : Ethylène(trichloro), Toxicité, Solvant organique, Rein, Appareil urinaire pathologie, Exposition professionnelle, Médecine travail, Homme, Long terme, Toxicité retardée, Tubule rénal, Marqueur biologique, Surveillance biologique, Glutathione transferase, Transferases, Enzyme, Urine, Liquide biologique

    Mots-clés Pascal anglais : Ethylene(trichloro), Toxicity, Organic solvent, Kidney, Urinary system disease, Occupational exposure, Occupational medicine, Human, Long term, Delayed toxicity, Renal tubule, Biological marker, Biological monitoring, Glutathione transferase, Transferases, Enzyme, Urine, Biological fluid

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0419068

    Code Inist : 002B03L04. Création : 22/03/2000.