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  1. Haemoglobin adducts of acrylonitrile and ethylene oxide in acrylonitrile workers, dependent on polymorphisms of the glutathione transferases GSTT1 and GSTM1.

    Article - En anglais

    Fifty-nine persons with industrial handling of low levels of acrylonitrile (AN) were studied.

    As part of a medical surveillance programme an extended haemoglobin adduct monitoring [N- (cyanoethyl) valine, CEV ; N- (methyl) valine, MV ; N- (hydroxyethyl) valine, HEV] was performed.

    Moreover, the genetic states of the polymorphic glutathione transferases GSTM1 and GSTTI were assayed by polymerase chain reaction (PCR).

    Repetitive analyses of CEV and MV in subsequent years resulted in comparable values (means, 59.8 and 70.3 mug CEV/I blood ; 6.7 and 6.7 mug MV/I blood).

    Hence, the industrial AN exposures were well below current official standards.

    Monitoring the haemoglobin adduct CEV appears as a suitable means of biomonitoring and medical surveillance under such exposure conditions.

    There was also no apparent correlation between the CEV and HEV or CEV and MV adduct levels.

    The MV and HEV values observed represented background levels, which apparently are not related to any occupational chemical exposure.

    There was no consistent effect of the genetic GSTMI or GSTTI state on CEV adduct levels induced by acrylonitrile exposure.

    Therefore, neither GSTM1 nor GSTTI appears as a major AN metabolizing isoenzyme in humans.

    The low and physiological background levels of MV were also not influenced by the genetic GSTM 1 state, but the MV adduct levels tended to be higher in GSTT1-individuals compared to GSTT1+persons. (...)

    Mots-clés Pascal : Acrylonitrile, Oxirane, Exposition professionnelle, Médecine travail, Surveillance biologique, Adduit moléculaire, Hémoglobine, Homme, Polymorphisme, Génétique, Toxicogénétique, Détoxication, Relation métabolisme toxicité, Glutathione transferase, Transferases, Enzyme

    Mots-clés Pascal anglais : Acrylonitrile, Ethylene oxide, Occupational exposure, Occupational medicine, Biological monitoring, Molecular adduct, Hemoglobin, Human, Polymorphism, Genetics, Toxicogenetics, Detoxication, Metabolism toxicity relation, Glutathione transferase, Transferases, Enzyme

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0419061

    Code Inist : 002B03L06. Création : 22/03/2000.