To determine the effect of exposure to chorioamnionitis on developmental outcome in very low birth weight (VLBW) infants.
Five hundred four maternal charts (97% of all VLBW infants delivered from 1990 to 1994) were reviewed.
A historical cohort study of the 330 infants delivered secondary to preterm premature rupture of membranes or preterm labor was performed.
Case subjects (71) were delivered of mothers with chorioamnionitis by clinical criteria ; control subjects (259) were delivered of mothers without chorioamnionitis.
Bayley index scores at 7 months'corrected age and special care nursery outcomes were compared.
One hundred seventy-three subjects were necessary to reject the two-sided null hypothesis with 80% power with a difference in mean Bayley index scores of at least 8. Results : Neonatal sepsis (8.5% compared with 1.9% ; odds ratio [OR]=4.7,95% confidence interval [CI] 1.4,15.9, P=015) and a low 5-minute Apgar (72% compared with 55% ; OR=2.1, CI 1.2,3.8, P=012) occurred more frequently in the chorioamnionitis group.
One hundred eighty-seven (68%) of 273 surviving neonates had follow-up.
Cases and controls were similar in mean Bayley mental developmental index (91.2 compared with 91.8, P=84), Bayley psychomotor developmental index (89.8 compared with 89.1, P=82), and number of infants developmentally delayed.
Duration of exposure to chorioamnionitis did not affect neonatal outcome. (...)
Mots-clés Pascal : Chorioamnionite, Mère, Poids naissance très faible, Epidémiologie, Pronostic, Nouveau né, Homme, Etude cohorte, Prématuré, Gestation pathologie, Foetus pathologie, Accouchement pathologie, Placenta pathologie, Nouveau né pathologie
Mots-clés Pascal anglais : Chorioamnionitis, Mother, Very low birthweight, Epidemiology, Prognosis, Newborn, Human, Cohort study, Premature, Pregnancy disorders, Fetal diseases, Delivery disorders, Placenta diseases, Newborn diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0418066
Code Inist : 002B20F02. Création : 22/03/2000.