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  1. Multiroute exposure assessment and excretion of urinary metabolites of fenitrothion during manual operations on treated ornamental plants in greenhouses.

    Article - En anglais

    The results of environmental and biological (five subjects) monitoring of exposure to fenitrothion during manual operations on treated ornamental plants in greenhouses are reported.

    Urinary excretion [GM (GSD) ] of alkylphosphates [dimethylphosphate (DMP)+dimethylthiophosphate (DMTP) ] (nmol/g creat) was 244.8 (1.8), 174.0 (2.0), and 354.4 (1.6) respectively, on the first (Monday), third (Wednesday), and fifth (Friday) days of work.

    These levels were not significantly higher than those recorded in a control group (21 subjects) in which urinary excretion [GM (GSD) ] of DMP+DMTP was 102.8 (4.2) nmol/g creat.

    Air concentrations of fenitrothion (nmol/m3) ranged from 45.5 to 81.2 on Monday, 17.3 to 27.1 on Wednesday, and 9.7 to 19.1 on Friday.

    Dose estimates showed that the respiratory-absorbed doses of fenitrothion accounted, on the average (GM), for 94.7%, 93.1%, and 91.5% of the total absorbed dose on Monday, Wednesday, and Friday, respectively.

    Multiple regression analysis showed a significant correlation (r2=0.595) between urinary excretion of DMP+DMTP, respiratory-absorbed dose, and skin-absorbed dose, estimated on Monday and Wednesday.

    Total estimated absorbed doses did not exceed the acceptable daily intake for fenitrothion.

    Serum and erythrocyte cholinesterase activities were not significantly different before and after exposure.

    Mots-clés Pascal : Exposition professionnelle, Insecticide, Pesticide, Médecine travail, Homme, Serre, Horticulture, Surveillance biologique, Urine, Liquide biologique, Excrétion, Pharmacocinétique, Toxicocinétique, Métabolite, Organophosphoré, Fenitrothion

    Mots-clés Pascal anglais : Occupational exposure, Insecticide, Pesticides, Occupational medicine, Human, Greenhouse, Horticulture, Biological monitoring, Urine, Biological fluid, Excretion, Pharmacokinetics, Toxicokinetics, Metabolite, Organophosphorus compounds, Fenitrothion

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0416123

    Code Inist : 002B03G. Création : 22/03/2000.