Until now, no survey had been conducted to assess the prevalence of respiratory symptoms in a large population that had been occupationally exposed to isocyanates, compared with that in a control group.
We performed such a survey, using questionnaires administered by occupational physicians.
Overall, 1114 workers'questionnaires (585 exposed and 529 control) were analyzed.
Exposed workers, primarily painters from small factories, reported significantly (P<0.05) more wheezing (8.6% vs 3.6%), more breathlessness with wheezing (3.4% vs 0.6%) in the last year, and more rhinitis (33.1% vs 19.1%) than did control workers.
A trend for more asthma (2.1% vs 0.8% ; P <= 0.07) was also observed.
Furthermore, 16.4%, 16.2%, and 10.6% of exposed workers reported (respectively) cough, rhinitis, and chest tightness when working in contact with isocyanates.
We conclude that isocyanate-exposed workers demonstrate significantly higher prevalence rates of rhinitic and asthmatic symptoms than do control subjects.
Mots-clés Pascal : Isocyanate organique, Toxicité, Exposition professionnelle, Médecine travail, Homme, Autoévaluation, Appareil respiratoire pathologie, Epidémiologie, Asthme, Bouches du Rhône, Provence Alpes Côte d'Azur, France, Europe
Mots-clés Pascal anglais : Organic isocyanate, Toxicity, Occupational exposure, Occupational medicine, Human, Self evaluation, Respiratory disease, Epidemiology, Asthma, Bouches du Rhône, Provence Alpes Côte d'Azur, France, Europe
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0415928
Code Inist : 002B03L06. Création : 22/03/2000.