A nested case-control study was conducted to examine the association between serum concentrations of 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene (DDE), the primary metabolite of 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT), and polychlorinated biphenyls (PCBs) and the development of breast cancer up to 20 years later.
Cases (n=346) and controls (n=346) were selected from cohorts of women who donated blood in 1974,1989, or both, and were matched on age, race, menopausal status, and month and year of blood donation.
Analyses were stratified by cohort participation because median DDE and PCB concentrations among the controls were 59 and 147% higher in 1974 than 1989, respectively.
Median concentrations of DDE were lower among cases than controls in both time periods [11.7% lower in 1974 (P=0.06) and 8.6% lower in 1989 (P=0.41) ]. Median concentrations of PCBs were similar among cases and controls [P=0.21 for 1974 and P=0.37 for 1989 (Wilcoxon signed rank test) ]. The risk of developing breast cancer among women with the highest concentrations of DDE was roughly half that among women with the lowest concentrations, whether based on concentrations in 1974 [odds ratio (OR), 0.50 ; 95% confidence interval (CI), 0.27-0.89 ; P trend=0.02] or in 1989 (OR, 0.53 ; 95% CI, 0.24-1.17 ; Ptrend=0.08).
The associations between circulating concentrations of PCBs and breast cancer were less pronounced but still in the same direction (1974 : OR, 0.68 ; 95% CI, 0.36-12. (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Organochloré, Concentration, Plasma sanguin, Exposition, Génotype, Epidémiologie, Facteur risque, Toxicité, Homme, Femelle, Etats Unis, Amérique du Nord, Amérique, Etude cas témoin, Glande mammaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Organochlorine compounds, Concentration, Blood plasma, Exposure, Genotype, Epidemiology, Risk factor, Toxicity, Human, Female, United States, North America, America, Case control study, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0413574
Code Inist : 002B20E02. Création : 22/03/2000.