The aim of this study was to assess changes in the clinical pattern of hepatitis D virus (HDV) infection in Italy, brought about by improved control of hepatitis B and D viruses, and to establish the natural history of chronic hepatitis D. Methods : Histological diagnosis and clinical features of 122 patients with HDV recruited from 1987 to 1996 in three Italian tertiary referral centers (Torino, northern Italy ; San Giovanni Rotondo and Castellana Grotte, southern Italy) were compared with those of 162 patients collected in the same centers in the previous decade.
Patients from both groups with at least 6 months of follow-up were included in a new subgroup to assess the natural history of the disease.
Among 162 patients referred from 1977 to 1986,9 (6%) had mild hepatitis at histology vs. 9 (8%) of 122 patients referred in the second decade ; 105 (65%) vs. 21 (17%) had severe hepatitis ; 46 (28%) vs. 38 (31%) had histological asymptomatic cirrhosis ; and 2 (1%) vs. 54 (44%) had clinically overt cirrhosis.
For 159 patients (121 men and 38 women ; mean age, 34 ± 11), a follow-up of more than 6 months was documented, and they were included in the natural history subgroup.
After 78 ± 59 months of follow-up, 112 (70%) survived free of liver transplantation : 9 underwent transplantation, 32 died of liver failure, and 6 of acquired immunodeficiency syndrome. (...)
Mots-clés Pascal : Hépatite virale, Virose, Infection, Chronique, Evolution, Modification, Indice gravité, Symptomatologie, Epidémiologie, Homme, Appareil digestif pathologie, Foie pathologie, Virus hépatite D
Mots-clés Pascal anglais : Viral hepatitis, Viral disease, Infection, Chronic, Evolution, Modification, Severity score, Symptomatology, Epidemiology, Human, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0413468
Code Inist : 002B05C02G. Création : 22/03/2000.