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  1. Possible relation of atypical parkinsonism In the French West indies with consumption of tropical plants : a case-control study.

    Article - En anglais

    Background In Europe and North America, Parkinson's disease is the major form of parkinsonism ; less than 4% of cases are progressive supranuclear palsy (PSP) and about 20% are atypical parkinsonism.

    The distribution of these subgroups is different in the French West Indies.

    We aimed to define the clinical and demographic specificity of these disorders in Guadeloupe and to investigate a postulated link with consumption of herbal tea and fruits from the Annonaceae family (Annona muricata and Annona squamosa), which contain neurotoxic benzyltetrahydro-isoquinoline alkaloids.

    Methods Between September, 1996, and August, 1998,87 consecutive patients with parkinsonism were referred to the single neurological department in Guadeloupe.

    After detailed clinical, neurophysiological, cognitive, and neuroradiological assessment, they were classified by generally accepted criteria as having Parkinson's disease, PSP, or atypical parkinsonism.

    We compared the amount of tropical fruits and herbal tea consumed by the various parkinsonian subgroups and by frequency-matched controls (patients with benign symptoms and no neurodegenerative disease).

    Findings Of the 87 patients, 22 had Parkinson's disease, 31 had PSP, 30 had atypical parkinsonism, and four had atypical parkinsonism associated with motor neuron disease, 44 of the patients with PSP or atypical parkinsonism were male. (...)

    Mots-clés Pascal : Parkinson maladie, Homme, Complication, Paralysie susnucléaire, Guadeloupe, Antilles, Amérique Centrale, Amérique, Etiologie, Alimentation, Régime alimentaire, Fruit, Thé, Alcaloïde, Parkinsonisme, France, Europe, Epidémiologie, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Extrapyramidal syndrome, Maladie dégénérative

    Mots-clés Pascal anglais : Parkinson disease, Human, Complication, Supranuclear paralysis, Guadeloupe, West Indies, Central America, America, Etiology, Feeding, Diet, Fruit, Tea, Alkaloid, Parkinsonism, France, Europe, Epidemiology, Nervous system diseases, Central nervous system disease, Cerebral disorder, Extrapyramidal syndrome, Degenerative disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0413450

    Code Inist : 002B17G. Création : 22/03/2000.