Background-Asthma outbreaks due to the inhalation of soybean dust released from handling of soybean in the city harbour occurred in Barcelona, Spain from 1981 to 1987.
The installation of bag filters in the responsible silo was followed by a substantial reduction of airborne soybean dust released into the atmosphere and the disappearance of asthma outbreaks.
A study was undertaken to assess the relevant outcomes in asthma patients affected by soybean epidemic asthma eight years after this environmental intervention.
Methods-A repeat case-control study was performed in 1995 on a population of subjects with epidemic and non-epidemic asthma previously assessed in 1989.
The same protocol was used in both surveys to collect data from patients via a questionnaire and respiratory function, skin and laboratory tests were performed under blinded conditions with regard to epidemic and non-epidemic status.
Environmental soybean allergen in pollution filters was measured by means of a RAST inhibition technique.
During 1995 and 1996 the 24 hour mean airborne levels of soybean allergen on a sample of 39 unloading days (range 31-269 U/m3) were systematically below the lowest level ever detected during an epidemic day (1500 U/m3).
Measurable levels of serum IgE antibodies against soybean were still present in 55% of patients with epidemic asthma compared with 6.0% of those with non-epidemic asthma (p<0.05).
These proportions were almost identical to those observed in 1989. (...)
Mots-clés Pascal : Asthme, Homme, Soja, Epidémie, Allergène, Espagne, Europe, Evolution, Etude comparative, Etiologie, Appareil respiratoire pathologie, Bronchopneumopathie obstructive
Mots-clés Pascal anglais : Asthma, Human, Soybean, Epidemic, Allergen, Spain, Europe, Evolution, Comparative study, Etiology, Respiratory disease, Obstructive pulmonary disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0411967
Code Inist : 002B11B. Création : 22/03/2000.