The oncogene product epidermal growth factor receptor (EGF-R), the tumour suppressor gene product p53 and anti-p53 antibodies are detectable in the serum of certain cancer patients.
Increased levels of some of these products were reported in lung cancer patients after occupational asbestos exposure and after exposure to polycyclic aromatic hydrocarbons or vinylchloride.
In the first step, this study investigated the possible diagnostic value of serum EGF-R, p53-protein and anti-p53 antibodies, measured by an enzyme-linked immunosorbent assay, in lung tumour patients.
In addition to being investigated on a molecular epidemiological basis, these parameters were examined as biomarkers of carcinogenesis, especially with regard to asbestos incorporation effects or of radon-induced lung cancers.
Also, a possible effect of cigarette smoking and age dependence were studied.
A total of 116 male patients with lung or pleural tumours were examined.
The histological classification was four small-cell cancers, six large-cell cancers, 32 adenocarcinomas, 47 squamous carcinomas, 12 mixed lung carcinomas, five diffuse malignant mesotheliomas and ten lung metastasis of extrapulmonary tumours.
Twenty-two lung cancers and all mesotheliomas were related to asbestos, 22 lung cancers were related to ionizing radiation and 61 patients had cigarette smoke-related lung cancer. (...)
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Facteur croissance épiderme, Récepteur membranaire, Récepteur biologique, Gène suppresseur tumeur, Gène TP53, Produit gène, Anticorps, Marqueur biologique, Allemagne, Europe, Exposition professionnelle, Amiante, Tabagisme, Rayonnement ionisant, Diagnostic, Précoce, Sérum, Homme, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Médecine travail, Maladie professionnelle, Génétique, Facteur croissance, Polypeptide, Cytokine
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Epidermal growth factor, Membrane receptor, Biological receptor, Tumor suppressor gene, TP53 Gene, Gene product, Antibody, Biological marker, Germany, Europe, Occupational exposure, Asbestos, Tobacco smoking, Ionizing radiation, Diagnosis, Early, Serum, Human, Respiratory disease, Lung disease, Bronchus disease, Occupational medicine, Occupational disease, Genetics, Growth factor, Polypeptide, Cytokine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0411235
Code Inist : 002B11A. Création : 22/03/2000.