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  1. Open drops in ophthalmology offices : Expiration and contamination.

    Article - En anglais


    To determine the relationship between eye drop use and contamination rate in ophthalmology offices.


    Following permission request, open bottles were examined and the nozzle tip and one drop of content was cultured on solid media.


    Drug category, volume, weight compared to full, clean legible label, expiration date ; 2 or more bacterial colonies along the inoculation site.


    In 18 offices, of 1,485 open bottles (mean 12.2, range 4 to 23 per lane) on average 19.8% (range 0% to 88%) were expired (16.2 of 82.5 bottles per office).

    The frequency of occurrence (%) and expiration (% E) were 40.3% cycloplegics (19.4% E) ; 16.4% glaucoma (33.7% E) ; 10.8% anesthetics (8.8% E) ; and 4% steroids (8.8% E ; or 42.2% E including one outlier).

    Most likely expired were glaucoma (P<0.001) ; small 2-3 ml (P<0.02), nearly empty (P<0.05), or dirty (P<0.001) bottles.

    Only one (5 ml cyclopentolate, not expired) grew a Micrococcus (0.07%). CONCLUSIONS : Drops in ophthalmology offices may be expired but are not contaminated.

    Mots-clés Pascal : Cabinet médical, Ophtalmologie, Collyre, Voie locale, Oeil, Médicament, Exploration, Contamination, Expiration, Enquête, Homme

    Mots-clés Pascal anglais : Doctor office, Ophthalmology, Eye drop, Local administration, Eye, Drug, Exploration, Contamination, Expiration, Survey, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0411179

    Code Inist : 002B30A05. Création : 22/03/2000.