The incidence of breast cancer has been greatly increasing in Taiwan over the past two decades.
Since cytochrome P4501A1 (CYP1A1) is involved in the metabolism of environmental carcinogens or oestrogen, we hypothesized that CYP1A1 genetic polymorphism may be a susceptibility factor for breast cancer.
This hypothesis was evaluated in this case control study of 150 breast cancer patients and 150 healthy controls among Chinese women.
Two CYP1A1 polymorphisms were studied, one containing a new Mspl site and the other located in axon 7 and resulting in the replacement of an isoleucine (lle) residue by a valine (Val).
After simultaneously considering the known or significant risk factors for breast cancer, including the age of study participants, positive family history of breast cancer, early menarche (<= 13 years), nulliparity and late first full-term pregnancy (>= 30 years), hormone replacement therapy and smoking, the CYP1A1 Mspl polymorphism was found to be a significant factor in determining the risk of breast cancer.
The homozygous variant was the most susceptible genotype with an adjusted odds ratio of 1.98 (95% confidence interval (Cl)=1.01-3.99) compared with the non-homozygous variants (the homozygous wild-type and the heterozygous variant).
In contrast, the CYP1A1 Ile/Val polymorphism was not significantly associated with breast cancer development (adjusted OR=1.07,95% Cl=0.64-1.78). (...)
Mots-clés Pascal : Carcinome, Glande mammaire, Facteur risque, Epidémiologie, Polymorphisme, Cytochrome P450, Forme moléculaire, Variabilité génétique, Génotype, Postménopause, Taiwan, Asie, Etude cas témoin, Femelle, Homme, Tumeur maligne, Glande mammaire pathologie, Génétique, Cytochrome P4501A1
Mots-clés Pascal anglais : Carcinoma, Mammary gland, Risk factor, Epidemiology, Polymorphism, Cytochrome P450, Molecular form, Genetic variability, Genotype, Postmenopause, Taiwan, Asia, Case control study, Female, Human, Malignant tumor, Mammary gland diseases, Genetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0409093
Code Inist : 002B20E02. Création : 22/03/2000.