logo BDSP

Base documentaire

  1. Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis.

    Article - En anglais

    Prepubertal exposure to a pharmacological dose (500 mg kg-1) of the phyto-oestrogen genistein can reduce the incidence and multiplicity of carcinogen-induced mammary tumours in rats.

    However, such an exposure also disrupts the function of the hypothalamic-pituitary-gonadal axis, making it unsuitable for breast cancer prevention.

    We studied whether prepubertal exposure to genistein at a total body dose broadly comparable to the level typical of Oriental countries, approximately 1 mg kg-1 body weight, affects mammary tumorigenesis.

    We also studied whether prepubertal exposure to zearalenone, a major source for phyto-oestrogens in the USA, influences breast cancer risk.

    Prepubertal rats were treated between postnatal days 7 and 20, with 20 mug (-1 mg kg-1 body weight) of either genistein or zearalenone.

    Zearalenone exposure significantly reduced both the incidence and multiplicity of mammary tumours induced by 7,12-dimethyibenz (a) anthracene (DMBA).

    Genistein exposure significantly reduced tumour multiplicity, but not tumour incidence, when compared with vehicle-treated animals.

    Furthermore, 60% of the tumours in the genistein group were not malignant, while all the tumours analysed for histopathology in the vehicle and zearalenone groups were adenocarcinomas.

    A higher number of differentiated alveolar buds, and lower number of terminal ducts, were present in the DMBA-treated mammary glands of the phyto-oestrogen exposed rats. (...)

    Mots-clés Pascal : Adénocarcinome, Glande mammaire, Facteur risque, Oestrogène, Phytohormone, Exposition, Zéaralénone, Tumorigénicité, Epidémiologie, Modèle animal, Rat, Rodentia, Mammalia, Vertebrata, Animal, Tumeur maligne, Glande mammaire pathologie, Hormone stéroïde sexuelle, Hormone ovarienne

    Mots-clés Pascal anglais : Adenocarcinoma, Mammary gland, Risk factor, Estrogen, Phytohormone, Exposure, Zearalenone, Tumorigenicity, Epidemiology, Animal model, Rat, Rodentia, Mammalia, Vertebrata, Animal, Malignant tumor, Mammary gland diseases, Sex steroid hormone, Ovarian hormone

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0406441

    Code Inist : 002B04D12. Création : 22/03/2000.