Risk assessment of lung cancer and mesothelioma in people living near asbestos-related factories in Taiwan.
Estimates from environmental risk assessments are criticized by professionals who indicate that inaccuracies occur in exposure assessment, model selection, and determination of the population at risk.
In the current study, we tackled the aforementioned issues and estimated the risks of lung cancer and mesothelioma caused by airborne asbestos among individuals who lived near asbestos factories in Taiwan.
We conducted 8-h full-period samplings upwind and downwind from each factory, and we used transmission-electronic microscopy (10 000x) and phase-contrast microscopy to determine asbestos concentrations in and around each factory.
We estimated the numbers of residents who lived in concentric circles of 200-m, 400-m, and 600-m diameters around each factory.
A dose-response model for asbestos-induced lung cancer was adopted from a summary of seven epidemiological studies.
The asbestos-mesothelioma models were patterned after the first-exposure-effect models developed by Peto and Finkelstein.
The data obtained from phase-contrast microscopy significantly overestimated the risk, compared with transmission-electronic microscopy.
The estimates we calculated from adopting the arithmetic mean were approximately 2-fold higher than those we calculated with the geometric mean.
There were relatively low concentrations of asbestos in the study areas, thus causing an absence of a significant difference in risk estimates between different models for mesothelioma. (...)
Mots-clés Pascal : Amiante, Industrie extractive, Proximité, Zone résidentielle, Zone industrielle, Tumeur maligne, Bronchopulmonaire, Mésothéliome malin, Facteur risque, Homme, Evaluation, Pollution air, Taiwan, Asie, Exposition, Non professionnel, Toxicité, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Asbestos, Mining industry, Proximity, Residential zone, Industrial area, Malignant tumor, Bronchopulmonary, Malignant mesothelioma, Risk factor, Human, Evaluation, Air pollution, Taiwan, Asia, Exposure, Non occupational, Toxicity, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0406165
Code Inist : 002B11A. Création : 22/03/2000.