The degree of glycaemia has been shown to be associated with all-cause and cardiovascular mortality in diabetic subjects.
Whether this association also exists in the general population is still controversial.
We studied the predictive value of fasting plasma glucose, 2-hour post-load glucose and HbA1c in a population-based cohort of 2363 older (50-75 years) subjects, without known diabetes.
Relative risks (RR) of all-cause and cardiovascular mortality were estimated by Cox proportional hazards model, adjusting for age and sex, and additionally for known cardiovascular risk factors.
During 8 years of follow-up, 185 subjects died ; 98 of cardiovascular causes.
Fasting plasma glucose was only predictive in the diabetic range, although the risks started to increase at about 6.1 mmol/l. Post-load glucose and HbA1 cvalues were, even within the non-diabetic range, associated with an increased risk (p for linear trend<0.05).
These increased risks were mostly, but not completely, attributable to known cardiovascular risk factors.
After exclusion of subjects with newly diagnosed diabetes or with pre-existent cardiovascular disease (n=551), a 5.8 mmol/l increase of post-load glucose (corresponding to two standard deviations of the population distribution) was associated with a higher age-adjusted and sex-adjusted risk of all-cause (RR 2.24) and cardiovascular mortality (RR 3.40) (p<0.05). (...)
Mots-clés Pascal : Mortalité, Glycémie, Association, Facteur risque, Personne âgée, Homme, Hyperglycémie, Appareil circulatoire pathologie, Pays Bas, Europe, Etude longitudinale, Epidémiologie
Mots-clés Pascal anglais : Mortality, Glycemia, Association, Risk factor, Elderly, Human, Hyperglycemia, Cardiovascular disease, Netherlands, Europe, Follow up study, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0405852
Code Inist : 002B21E01A. Création : 22/03/2000.