Noradrenaline, adrenaline and dopamine levels were measured using high-performance liquid chromatography (HPLC) and electrochemical detection and related to urine creatinine in 30 specimens from unselected autopsies.
Values calculated from patients with essential hypertension were used as a reference and raised values of noradrenaline, adrenaline and dopamine were found in 76.6,80 and 23.3%, respectively.
Using the Mann-Whitney U test, there was no difference between the 11 patients with myocardial infarction and the seven who died from severe head injury or multiple trauma.
The median values in mmol/mol creatinine for patients with myocardial infarction and trauma were 0.07 and 0.12 for noradrenaline and 0.012 and 0.024 for adrenaline, respectively.
Physiological stress is common before death and urine noradrenaline values at autopsy overlap those found in some normal subjects and at autopsy in patients with phaeochromocytoma.
Mots-clés Pascal : Mort, Urine, Prélèvement, Analyse biochimique, Exploration hormonale, Postmortem, Catécholamine, Chromatographie HPLC, Autopsie, Stress, Homme
Mots-clés Pascal anglais : Death, Urine, Samplings, Biochemical analysis, Hormonal investigation, Postmortem, Catecholamine, HPLC chromatography, Autopsy, Stress, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0405809
Code Inist : 002B30A10. Création : 22/03/2000.