Total homocysteine and cognitive decline in a community-based sample of elderly subjects : The Rotterdam Study.
Homocysteine has been associated with an increased risk of cardiovascular disease.
Cardiovascular diseases have been related to cognitive decline.
The authors investigated the association of homocysteine with concurrent cognitive impairment and subsequent cognitive decline in a random sample of 702 community-dwelling respondents aged 55 years or over to the prospective Rotterdam Study in 1990-1994.
Multiple logistic regression was used to calculate odds ratios and 95 percent confidence intervals for the association between total homocysteine levels and cognitive impairment (Mini-Mental State Examination (MMSE) score<26) and cognitive decline (drop in MMSE score of>1 point/year).
Mean duration of follow-up was 2.7 years.
After adjustment for age, sex, and education, there was no relation between total homocysteine and cognitive impairment (highest vs. lowest tertile : odds ratio (OR)=1.30,95% confidence interval (Cl) : 0.50,3.38) or cognitive decline (middle vs. lowest tertile : OR=1.14,95% Cl : 0.67,1.93 ; highest vs. lowest tertile : OR=0.91,95% Cl : 0.52,1.58).
Subjects who were lost to follow-up due to death or nonresponse had slightly higher age-adjusted homocysteine levels and lower MMSE scores at baseline.
Sensitivity analyses showed that selective loss to follow-up was not a likely explanation for the absence of an association in the participants. (...)
Mots-clés Pascal : Démence sénile, Personne âgée, Homme, Complication, Cognition, Facteur risque, Analyse biochimique, Athérosclérose, Homocystéine, Pays Bas, Europe, Epidémiologie, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Senile dementia, Elderly, Human, Complication, Cognition, Risk factor, Biochemical analysis, Atherosclerosis, Netherlands, Europe, Epidemiology, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0404305
Code Inist : 002B17G. Création : 22/03/2000.