Background-The effect of hypertension on mortality was examined in 5284 Pima Indians, 1698 of whom had type 2 diabetes at baseline or developed it during follow-up.
Methods and Results-During a median follow-up of 12.2 years (range, 0.01 to 24.8 years), 470 nondiabetic subjects and 488 diabetic subjects died.
In the nondiabetic subjects, 45 of the deaths were due to cardiovascular disease, 208 to other natural causes, and 217 to external causes ; in the diabetic subjects, 106 of the deaths were due to cardiovascular disease, 85 to diabetic nephropathy, 226 to other natural causes, and 71 to external causes.
In the nondiabetic subjects, after adjusting for age, sex, body mass index, and serum cholesterol concentration in a proportional hazards model, hypertension predicted death from cardiovascular disease (death rate ratio [DRR]=2.8 ; 95% Cl, 1.4 to 5.6 ; P=0.003).
In the diabetic subjects, after additional adjustment for duration of diabetes, plasma glucose concentration, and proteinuria, hypertension strongly predicted deaths from diabetic nephropathy (DRR=3.5 ; 95% CI, 1.7 to 7.2 ; P<0.001), but it had little effect on deaths from cardiovascular disease (DRR=1.4 ; 95% CI, 0.88 to 2.3 ; P=0.15). (...)
Mots-clés Pascal : Hypertension artérielle, Homme, Amérindien, Diabète, Association morbide, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Mortalité, Pronostic, Appareil circulatoire pathologie, Complication, Facteur risque, Endocrinopathie
Mots-clés Pascal anglais : Hypertension, Human, Amerindian, Diabetes mellitus, Concomitant disease, Epidemiology, United States, North America, America, Mortality, Prognosis, Cardiovascular disease, Complication, Risk factor, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0403254
Code Inist : 002B12B05B. Création : 22/03/2000.