Gallbladder carcinoma is a highly lethal disease.
The advantages of radical surgery remain controversial.
The authors'objective was to evaluate the effectiveness of an aggressive approach to gallbladder carcinoma on long-term survival.
A questionnaire was sent to 73 institutions in France, Europe, and overseas.
Data, from 724 patients treated between 1980 and 1989, were analyzed for patient sex and age, associated hepatobiliary diseases, symptoms and signs, diagnostic tests, operative management, pathology reports and survival.
Seventy-eight percent of the patients were women, and 22% were men.
Gallstones were present in 86% of the cases.
Four percent of the patients had Tis lesions, 11% had T1 to T2 lesions, and 85% had T3 to T4 lesions.
Twenty-three percent of the patients underwent curative operations, and 77% had a palliative treatment (25% of the patients underwent exploratory laparotomy).
Exploratory laparotomy was followed by the highest mortality rate (66%), and older patients (>70 years) had a higher operative risk.
The overall median survival was 3 months, and long-term survival correlated with cancer stage : Tis>60 months, T1 to T2>22 months, and T3 to T4 2 to 8 months.
Projected five-year survival for cancers limited to the gallbladder and treated by simple cholecystectomy was 93%, 18% and 10% for Tis, T1 and T2 respectively. (...)
Mots-clés Pascal : Vésicule biliaire, Tumeur maligne, Questionnaire, Chirurgie, Radical, Evaluation, Survie, Long terme, Etude comparative, Méthodologie, France, Europe, Association, Chirurgien, Homme, Appareil digestif pathologie, Voie biliaire pathologie, Technique
Mots-clés Pascal anglais : Gallbladder, Malignant tumor, Questionnaire, Surgery, Radical, Evaluation, Survival, Long term, Comparative study, Methodology, France, Europe, Association, Surgeon, Human, Digestive diseases, Biliary tract disease, Technique
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0403187
Code Inist : 002B25G03. Création : 22/03/2000.