AMERICAN JOURNAL OF EPIDEMIOLOGY, vol. 150, n° 3, 1999, pages 245-254, 35 réf., ISSN 0002-9262, USA
CHIARELLI (A.M.), MARRETT (L.D.), DARLINGTON (G.) *
Division of Preventive Oncology. Cancer Care Ontario. Toronto. ON. CAN, Department of Public Health Sciences. University of Toronto. Toronto. ON. CAN
This study was conducted to determine the risk of menopause and infertility in female childhood cancer survivors who received abdominal-pelvic radiation and/or chemotherapy with alkylating agents in comparison with those who were treated by nonsterilizing surgery only.
Females who were diagnosed in 1964-1988 before age 20 years with a histologically confirmed malignancy and who had survived for at least 5 years, had attained age 18, and were alive at time of study were identified through the Ontario Cancer Registry.
Reproductive outcomes were ascertained by a telephone-administered questionnaire, and treatment data were abstracted from medical records for 830 subjects aged 18-49 years ; 719 survivors who were nonmenopausal at the end of treatment were included in the analyses.
Survivors who received both alkylating agents and abdominal-pelvic radiation were more likely to be postmenopausal than were those who underwent surgery (risk ratio=2.58 ; 95% confidence interval : 1.14,5.80).
Women treated with abdominal-pelvic radiation alone had a fertility deficit of 23% compared with those in the surgery group ; the deficit was restricted to women diagnosed postpuberty.
Risks of menopause and infertility increased with increasing dose of abdominal-pelvic radiation and amount of alkylating agent.
Mots-clés BDSP : Homme, Femme, Complication, Thérapeutique, Radiothérapie, Thérapeutique médicamenteuse, Médicament anticancéreux, Canada, Amérique, Epidémiologie, Amérique du Nord
Mots-clés Pascal : Stérilité femelle, Ménopause précoce, Homme, Femelle, Complication, Traitement, Toxicité, Radiothérapie, Chimiothérapie, Anticancéreux, Agent alkylant, Etude cohorte, Canada, Amérique du Nord, Amérique, Epidémiologie
Mots-clés Pascal anglais : Female sterility, Premature menopause, Human, Female, Complication, Treatment, Toxicity, Radiotherapy, Chemotherapy, Antineoplastic agent, Alkylating agent, Cohort study, Canada, North America, America, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0403180
Code Inist : 002B02U06. Création : 22/03/2000.