Early menopause and infertility in females after treatment for childhood Cancer diagnosed in 1964-1988 in Ontario, Canada.
This study was conducted to determine the risk of menopause and infertility in female childhood cancer survivors who received abdominal-pelvic radiation and/or chemotherapy with alkylating agents in comparison with those who were treated by nonsterilizing surgery only.
Females who were diagnosed in 1964-1988 before age 20 years with a histologically confirmed malignancy and who had survived for at least 5 years, had attained age 18, and were alive at time of study were identified through the Ontario Cancer Registry.
Reproductive outcomes were ascertained by a telephone-administered questionnaire, and treatment data were abstracted from medical records for 830 subjects aged 18-49 years ; 719 survivors who were nonmenopausal at the end of treatment were included in the analyses.
Survivors who received both alkylating agents and abdominal-pelvic radiation were more likely to be postmenopausal than were those who underwent surgery (risk ratio=2.58 ; 95% confidence interval : 1.14,5.80).
Women treated with abdominal-pelvic radiation alone had a fertility deficit of 23% compared with those in the surgery group ; the deficit was restricted to women diagnosed postpuberty.
Risks of menopause and infertility increased with increasing dose of abdominal-pelvic radiation and amount of alkylating agent.
Mots-clés Pascal : Stérilité femelle, Ménopause précoce, Homme, Femelle, Complication, Traitement, Toxicité, Radiothérapie, Chimiothérapie, Anticancéreux, Agent alkylant, Etude cohorte, Canada, Amérique du Nord, Amérique, Epidémiologie
Mots-clés Pascal anglais : Female sterility, Premature menopause, Human, Female, Complication, Treatment, Toxicity, Radiotherapy, Chemotherapy, Antineoplastic agent, Alkylating agent, Cohort study, Canada, North America, America, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0403180
Code Inist : 002B02U06. Création : 22/03/2000.