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  1. Response to activated protein C in subjects with and without dementia : The Dutch vascular factors in dementia study.

    Article - En anglais

    We performed a cross-sectional case-control study among 295 subjects with dementia and 406 control subjects drawn from participants of the Rotterdam Study, a population-based cohort study among subjects aged 55 years or over, and from participants of the Rotterdam Stroke Databank, a hospital-based stroke registry, to evaluate the association of the factor V Leiden mutation and activated protein C (APC) response with dementia and its subtypes.

    The risk of dementia was 2.11-fold increased among carriers of factor V Leiden mutation relative to subjects lacking factor V Leiden mutation (95% confidence interval, Cl, 0.93-4.77).

    The increased risks of vascular dementia and of Alzheimer's disease were 4.28 (95% CI 1.26-14.5) and 2.15 (95% Cl 0.82-5.63), respectively.

    No association was found for APC response.

    We showed a nonsignificant twofold increased risk of dementia among subjects with factor V Leiden.

    The association appeared to be stronger for vascular dementia.

    Mots-clés Pascal : Démence Alzheimer, Trouble cognition, Démence vasculaire, Facteur V Leiden, Résistance, Protein C (activated), Serine endopeptidases, Peptidases, Hydrolases, Enzyme, Facteur risque, Epidémiologie, Pays Bas, Europe, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Hémopathie, Coagulopathie, Maladie héréditaire

    Mots-clés Pascal anglais : Alzheimer disease, Cognitive disorder, Vascular dementia, Factor V Leiden, Resistance, Protein C (activated), Serine endopeptidases, Peptidases, Hydrolases, Enzyme, Risk factor, Epidemiology, Netherlands, Europe, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease, Cardiovascular disease, Vascular disease, Hemopathy, Coagulopathy, Genetic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0403136

    Code Inist : 002B17G. Création : 22/03/2000.