The Bangladesh Acute Nerve Damage Study (BANDS) is a prospective cohort study designed to investigate epidemiological, diagnostic, therapeutic and operational aspects of acute nerve function impairment in leprosy.
The study is based at a single centre in Bangladesh, in an area with a high prevalence of leprosy.
The centre, Danish Bangladesh Leprosy Mission, has a well-established vertical leprosy control programme.
In this paper, the study design and methodology are described, together with definitions of nerve function impairment (NFI) used in this and subsequent papers.
The study recruited 2664 new leprosy cases in a 12-month period.
The male : female ratio is 1.25 : 1, and 17.61% of the cohort are under 15 years of age.
In all, 83.33% of the cohort are paucibacillary (PB), and 16.67% multibacillary (MB) However, the MB rate amongst males is 19.72%, and amongst females is 12.85%, despite an equal period of delay to diagnosis. 55% of patients presented for treatment within 12 months of developing symptoms. 6.12% of the total number of cases were smear positive, and 3671% of the MB cases were smear positive. 9.1% of the total number of cases were graded as having World Health Organisation (WHO) disability grade 1, and 5.97% had grade 2. Amongst MB cases, 27.48% had WHO grade 1 disability present, and 18.24% had grade 2 present, compared with 6.04% and 3.51%, respectively, amongst PB cases.
A total of 11.90% of the cohort had sensory NFI of any kind, and 7. (...)
Mots-clés Pascal : Lèpre, Mycobactériose, Bactériose, Infection, Epidémiologie, Lésion, Nerf périphérique, Aigu, Surveillance, Méthodologie, Bengla Desh, Asie, Homme, Etude cohorte, Peau pathologie
Mots-clés Pascal anglais : Leprosy, Mycobacterial infection, Bacteriosis, Infection, Epidemiology, Lesion, Peripheral nerve, Acute, Surveillance, Methodology, Bangladesh, Asia, Human, Cohort study, Skin disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0402193
Code Inist : 002B05B02L1. Création : 22/03/2000.