It has long been thought that an individual thrombotic tendency increases the risk of myocardial infarction, especially in young adults.
Several prothrombotic'genetic factors that may influence the individual thrombotic risk have been identified.
To investigate the association between the risk of myocardial infarction at a young age and genetic factors thought to be associated with an Increased tendency to thrombosis (the polymorphisms 4G/5G of the PAI-1 gene, PIA1/PIA2 of the platelet glycoprotein Illa, C3550T of the platelet glycoprotein Ib gene, G10976A of the factor VII gene, C677T of the methylenetetrahydrofolate reductase gene, G1691A of the factor V gene, and G20210A of the prothrombin gene), we performed a case-control study evaluating 200 survivors (185 men, 15 women) of myocardial infarction who had experienced the event before the age of 45 years and 200 healthy subjects with a negative exercise test, individually matched for sex, age, and geographic origin with the cases.
The presence of the PIA2 polymorphic allele was the only prothrombotic genetic factor associated with the risk of myocardial infarction at a young age.
The odds ratio for carriers of the PIA2 allele compared with those of the PIA1 allele was 1.84 (95% confidence intervals (Cl) 1.12 to 3.03). (...)
Mots-clés Pascal : Infarctus, Myocarde, Facteur risque, Epidémiologie, Polymorphisme, Gène, Variabilité génétique, Protéine membranaire, Glycoprotéine, Thrombocyte, Marqueur génétique, Tabagisme, Etude cas témoin, Italie, Europe, Homme, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie, Génétique, Glycoprotéine IIIa
Mots-clés Pascal anglais : Infarct, Myocardium, Risk factor, Epidemiology, Polymorphism, Gene, Genetic variability, Membrane protein, Glycoprotein, Platelet, Genetic marker, Tobacco smoking, Case control study, Italy, Europe, Human, Cardiovascular disease, Coronary heart disease, Myocardial disease, Genetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0399372
Code Inist : 002B12A03. Création : 22/03/2000.