Detection of antimicrobial activity in urine for epidemiologic studies of antibiotic use.
Antibiotic resistance is the inevitable consequence of the selective pressure of antimicrobial drug use and the adaptive plasticity of the microorganisms.
Excessive and irrational use of antimicrobial drugs is a problem in all countries.
It is particularly troublesome in developing countries where there is a heavy burden of infectious diseases.
This study was designed to determine whether detection of antimicrobial activity in the urine might be a useful tool for epidemiologic studies of the interaction between antibiotic use and resistance in developing countries.
A laboratory marker is necessary because the history of antimicrobial drug use may be unreliable.
Serial specimens or spontaneously voided urine were obtained from healthy volunteers given a single oral dose of commonly used antimicrobial drugs.
Urine was also obtained from hospitalized patients the morning after the last dose of an antimicrobial drug and from untreated controls.
Assays were performed with standard American Type Culture Collection (Rockville, MD) stains of Bacillus stearothermophilus, Escherichia coli, and Streptococcus pyogenes.
Antimicrobial activity could not be detected in pretreatment urine.
After a single oral dose, the bêta lactam antibiotics and erythromycin could be detected for about 12 to 24 hours, whereas clindamycin, tetracycline, trimethoprim/sulfamethoxazole, and ciprofloxacin could be detected for 48 or more hours. (...)
Mots-clés Pascal : Infection, Bactériose, Homme, Traitement, Chimiothérapie, Antibiotique, Antibactérien, Evolution, Résistance traitement, Dépistage, Technique, Activité biologique, Urine, Taiwan, Asie, Epidémiologie
Mots-clés Pascal anglais : Infection, Bacteriosis, Human, Treatment, Chemotherapy, Antibiotic, Antibacterial agent, Evolution, Negative therapeutic reaction, Medical screening, Technique, Biological activity, Urine, Taiwan, Asia, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0393965
Code Inist : 002B02S07. Création : 22/03/2000.