Consideration of individual susceptibility in adverse pesticide effects.
International Symposium on Health Aspects of Environmental and Occupational Pesticide Exposure. Düsseldorf, DEU, 1998/09/28.
The modern environmental awareness leads to the realisation that the human metabolism is stressed by a huge number of chemical substances.
Generally, these background exposures, consisting predominantly from natural and partly from industrial as well as life style sources, are tolerated without any adverse effects.
Pesticides are chemicals intentionally introduced to the environment and have become necessities in modern agriculture as well as in indoor pest control.
Their residues, therefore, is attracting more and more concern.
For the majority of pesticides neither occupational nor environmental medical risk evaluations are so far available.
Therefore, at the moment the occupational as well as the environmental supported preventive concept may only be achieved, if binding instructions upon experience and guide values are developed for the assessment of the individual risk of handling pesticides.
In the occupational and environmental pesticide prophylaxis the ubiquitous background exposure levels in consideration with individual susceptibility factors should be recommended as provisional biological tolerance guide values.
The suitability of this guide values concept for pesticides is demonstrated by determining the background exposure and the biomarkers of susceptibility of 250 unexposed persons as well as of more than 1200 occupationally exposed persons. (...)
Mots-clés Pascal : Toxicité, Composé chimique, Pesticide, Pollution, Exposition professionnelle, Médecine travail, Epidémiologie, Homme, Comparaison interindividuelle, Toxicocinétique, Pharmacocinétique, Métabolisme, Détoxication, Carbamate, Urées, Diuron, Propoxur, Dyrène, 1,3,5-Triazine(2,4-dichloro-5-[2-chloroanilino])
Mots-clés Pascal anglais : Toxicity, Chemical compound, Pesticides, Pollution, Occupational exposure, Occupational medicine, Epidemiology, Human, Interindividual comparison, Toxicokinetics, Pharmacokinetics, Metabolism, Detoxication, Carbamate, Ureas, Diuron
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Cote : 99-0393763
Code Inist : 002B03G. Création : 22/03/2000.