Few studies have investigated the relation between glucose tolerance status and ultrasonographically determined gallstone disease.
Using a 75-g oral glucose tolerance test, we examined the association of impaired glucose tolerance (IGT) and non-insulin-dependent diabetes mellitus (NIDDM) with gallstone disease in Japanese men.
Subjects were men aged 48 to 59 of the Japan Self-Defense Forces who received a preretirement health examination between October 1986 to December 1994.
After exclusion of 12 men under insulin treatment in the consecutive series of 7637 men, 174 were found to have gallstones ; 103 were at the state of postcholecystectomy, and 6899 had normal gallbladder.
IGT and NIDDM were associated with a modestly increased risk of gallstone disease ; adjusted odds ratios were 1.3 (95% confidence interval [CI] : 0.9-1.8) for IGT and 1.3 (95% CI : 0.8-2.0) for NIDDM after adjustment for hospital, rank, smoking, alcohol use, and body mass index.
Adjusted odds ratio for IGT and NIDDM combined was 1.3 (95% CI : 1.0-1.7, p=0.08).
When prevalent gallstones and postcholecystectomy were considered separately, NIDDM showed a significant, positive association with postcholecystectomy, but not with prevalent gallstones.
The findings add to evidence that glucose intolerance is associated with a modest increase in the risk of gallstone disease.
Mots-clés Pascal : Diabète non insulinodépendant, Anomalie tolérance glucose, Homme, Mâle, Association, Facteur risque, Lithiase, Vésicule biliaire, Japon, Asie, Epidémiologie, Prévalence, Endocrinopathie, Voie biliaire pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Non insulin dependent diabetes, Impaired glucose tolerance, Human, Male, Association, Risk factor, Lithiasis, Gallbladder, Japan, Asia, Epidemiology, Prevalence, Endocrinopathy, Biliary tract disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0393714
Code Inist : 002B13C03. Création : 22/03/2000.