A modest inverse association between lactation and breast cancer risk has most consistently been observed in premenopausal women, and certain breastfeeding patterns, such as prolonged duration and early age at first lactation, may be important determinants of risk.
However, these associations have not generally been observed in relation to postmenopausal breast cancer.
As part of a multicenter population-based case-control study, the authors examined postmenopausal breast cancer risk according to breastfeeding characteristics.
Breast cancer patients aged 50-79 years were identified from statewide tumor registries in Massachusetts, New Hampshire, and Wisconsin from July 1992 through July 1995.
Similarly aged control women were randomly selected from population lists.
Information regarding lactation history and breast cancer risk factors was obtained through telephone interviews.
This analysis included only data on parous postmenopausal women (3,633 cases and 3,790 controls).
After adjustment for age, parity, age at first birth, and other breast cancer risk factors, breastfeeding for at least 2 weeks was associated with a slightly reduced risk of breast cancer in comparison with women who had never lactated (relative risk=0.87,95% confidence interval 0.78-0.96).
There was only a modest suggestion that increasing cumulative duration of lactation was inversely associated with breast cancer risk (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Homme, Femelle, Ménopause, Protection, Lactation, Etude multicentrique, Durée, Etude cas témoin, Etats Unis, Amérique du Nord, Amérique, Epidémiologie, Glande mammaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Human, Female, Menopause, Protection, Lactation, Multicenter study, Duration, Case control study, United States, North America, America, Epidemiology, Mammary gland diseases
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0392740
Code Inist : 002B20E02. Création : 22/03/2000.