We undertook a meta-analysis of epidemiological studies investigating the relationship between occupational diesel exhaust exposure and long cancer.
Thuty of 47 studies initially identified as potentially relevant met specified inclusion criteris.
We extracted or calculated 39 independent estimates of relative risk and derived pooled estimates of risk for all studies and for numerous study sabsets by using a random-effects model.
We also examised interstudy heterogeneity by using linear metaregressions.
Results, There was substantial heterogeneity in the pooled risk estimates for all studies combined and for most subsets.
Several factors consistent with higher study quality, however, contributed to increased pooled estimates of risk and lower heterogeneity, including (1) adjustment for comfounding by eigarette smoking and other covariates, (2) having a lower likelihoed of selection bins, and (3) having increased study power.
The analysis provides quantitative support for prior qualitative reviews that have ascribed an etiologic role to accupational diesel exhaust exposure in lung cancer induction.
Among study populations most likely to have had substantial exposute to diesel exhaust, the pooled smoking-adjusted relative risk was 1,47 (95% confidence interval - 1.29,1.67).
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Homme, Facteur risque, Exposition professionnelle, Particule fine, Gas oil, Revue bibliographique, Métaanalyse, Etats Unis, Amérique du Nord, Amérique, Epidémiologie, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Human, Risk factor, Occupational exposure, Fine particle, Gas oil, Bibliographic review, Metaanalysis, United States, North America, America, Epidemiology, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0392605
Code Inist : 002B11A. Création : 22/03/2000.