Biological monitoring of exposure to pirimicarb : hydroxypyrimidines in human urine.
International Symposium on Health Aspects of Environmental and Occupational Pesticide Exposure. Düsseldorf, DEU, 1998/09/28.
Pirimicarb (2-dimethylamino-5,6-dimethylpyrimidin-4-yldimethylcarbamate) is used as insecticide in agriculture and fruit growing.
During its metabolism in mammals the carbamate moiety is hydrolysed and subsequent demethylation at the dimethylaminogroup which is attached to the heterocyclic moiety results in the following major metabolites which are excreted in urine : 2-dimethylamino-5,6-dimethyl-4-hydroxypyrimidine (DDHP), 2-methylamino-5,6-dimethyl-4-hydroxypyrimidine (MDHP), and 2-amino-5,6-dimethyl-4-hydroxypyrimidine (ADHP).
These metabolites were detected in every urine sample of seven workers who had applied pirimicarb.
Concentrations of the MDHP and ADHP were much higher than that of DDHP indicating a considerable demethylation capacity in humans.
No metabolites were found in urine specimens of controls.
The investigated pyrimidines represent sensitive and specific parameters for biological monitoring of exposure to pirimicarb.
Mots-clés Pascal : Toxicité, Pesticide, Insecticide, Carbamate organique, Pyrimidine dérivé, Surveillance biologique, Métabolite, Liquide biologique, Urine, Homme, Exposition professionnelle, Médecine travail, Primicarb, Pyrimidine-4-méthanol(6-hydroxy-2-diméthylamino-5-méthyl), Pyrimidin-4-ol(2-amino-5,6-diméthyl)
Mots-clés Pascal anglais : Toxicity, Pesticides, Insecticide, Organic carbamate, Pyrimidine derivatives, Biological monitoring, Metabolite, Biological fluid, Urine, Human, Occupational exposure, Occupational medicine
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0392376
Code Inist : 002B03G. Création : 22/03/2000.