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  1. Schizophrenia and the influenza epidemics of 1957 in Japan.

    Article - En anglais

    Background 

    We tested the hypothesis that the exposure to an influenza epidemic during the second trimester of gestation is associated with an increased risk of later development of schizophrenia.

    Methods 

    There were three influenza epidemics (A/B mixed type, the first A2 type and the second A2 type) in 1957 in Kochi, Japan.

    We compared the risk of developing schizophrenia in birth cohorts exposed to these three influenza epidemics during gestation with that in birth cohorts not exposed.

    To identify subjects who had developed schizophrenia, we surveyed patients with schizophrenia who received medical care at all psychiatric institutions in Kochi prefecture.

    Results 

    There is a pattern that schizophrenic births increase twice or more among female subjects who were exposed to each of three influenza epidemics in the fifth month of gestation.

    The increase in the female births exposed to the second A2 epidemic was significant (relative risk 2.86,95% confidence interval 1.37-5.26).

    This pattern across the three epidemics was not observed in male subjects.

    Conclusions 

    Prenatal exposure to an influenza epidemic during the second trimester increased the risk of later development of schizophrenia in female births.

    Mots-clés Pascal : Schizophrénie, Epidémiologie, Japon, Asie, Facteur risque, Exposition, Prénatal, Deuxième trimestre, Influenzavirus A, Orthomyxoviridae, Virus, Etiologie, Etude longitudinale, Santé mentale, Homme, Psychose

    Mots-clés Pascal anglais : Schizophrenia, Epidemiology, Japan, Asia, Risk factor, Exposure, Prenatal, Second trimester, Influenzavirus A, Orthomyxoviridae, Virus, Etiology, Follow up study, Mental health, Human, Psychosis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0391175

    Code Inist : 002B18C06A. Création : 22/03/2000.