International Symposium on Health Aspects of Environmental and Occupational Pesticide Exposure. Düsseldorf, DEU, 1998/09/28.
A study of endosulfan excretion in human urine was carried out by using an agricultural worker involved with spraying, wearing protective overall, gloves and breathing mask.
The urine samples were extracted with Solid Phase Extraction (SPE) cartridges and the compounds were separated and detected using Gas Chromatography-Tandem Mass Spectrometry (GC-MS/MS) due to their high sensitivity and selectivity in preventing most matrix interferences.
The alpha-and bêta-isomers of endosulfan were detected (total concentrations ranged between 5368 and 2239 pg/ml) but endosulfan-ether, - lactone or - sulphate were not found above the detection limits.
The results obtained were compared with the concentrations found for a non-occupational exposed man.
Statistical interpretation of the excretion-rate of the insecticide was performed by assuming that it can be described as a first-order kinetic.
The constant rate and the half-lives were determined.
Mots-clés Pascal : Toxicocinétique, Cinétique, Pharmacocinétique, Elimination, Urine, Liquide biologique, Homme, Isomère, Pesticide, Insecticide, Organochloré, Exposition professionnelle, Médecine travail, Vêtement protecteur, Masque protection, Méthode couplée, Chromatographie phase gazeuse, Spectrométrie masse, Extraction SPE, Endosulfan, Cyclodiène dérivé
Mots-clés Pascal anglais : Toxicokinetics, Kinetics, Pharmacokinetics, Elimination, Urine, Biological fluid, Human, Isomer, Pesticides, Insecticide, Organochlorine compounds, Occupational exposure, Occupational medicine, Protective clothing, Protective mask, Coupled method, Gas chromatography, Mass spectrometry, Solid phase extraction
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0390724
Code Inist : 002B03G. Création : 22/03/2000.