The Role of Epidemiology in Determining when Evidence is Sufficient to Support Nutrition Recommendations. Worshop. Washington, DC, USA, 1997/10/07.
The conflicting evidence of the relation between bêta-carotene and lung cancer in humans serves as a poignant case study with respect to what types of evidence are sufficient to support or change a nutrition recommendation.
This article is a review of the available evidence of the relation between bêta-carotene and lung cancer, including data regarding bêta-carotene intake (from diet and supplements), bêta-carotene biochemical status, and vegetable and fruit consumption, and a discussion of the role of this evidence in making nutrition recommendations.
More than 30 case-control and cohort studies were conducted over many years in various populations and indicated that people who eat more vegetables and fruit, foods rich in carotenoids, and carotenoids (bêta-carotene in particular), as well as those with higher blood bêta-carotene concentrations, have a lower risk of lung cancer than those who eat fewer such foods or have lower bêta-carotene concentrations.
In contrast, the intervention results from large, controlled trials of bêta-carotene supplementation do not support the observed beneficial associations or a role for supplemental bêta-carotene in lung cancer prevention ; instead, they provide striking evidence for adverse effects (ie, excess lung cancer incidence and overall mortality) in smokers. (...)
Mots-clés Pascal : Etude cas, Bétacarotène, Consommation alimentaire, Antioxydant, Epidémiologie, Recommandation alimentaire, Essai clinique, Tumeur maligne, Bronchopulmonaire, Prévention, Caroténoïde, Vitamine, Comportement alimentaire, Alimentation, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Homme
Mots-clés Pascal anglais : Case study, Betacarotene, Food intake, Antioxidant, Epidemiology, Dietary allowance, Clinical trial, Malignant tumor, Bronchopulmonary, Prevention, Carotenoid, Vitamin, Feeding behavior, Feeding, Respiratory disease, Lung disease, Bronchus disease, Human
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0387957
Code Inist : 002B11A. Création : 22/03/2000.