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  1. Fulltext. bêta-carotene and lung cancer : a case study.

    Article, Communication - En anglais


    The Role of Epidemiology in Determining when Evidence is Sufficient to Support Nutrition Recommendations. Worshop. Washington, DC, USA, 1997/10/07.

    The conflicting evidence of the relation between bêta-carotene and lung cancer in humans serves as a poignant case study with respect to what types of evidence are sufficient to support or change a nutrition recommendation.

    This article is a review of the available evidence of the relation between bêta-carotene and lung cancer, including data regarding bêta-carotene intake (from diet and supplements), bêta-carotene biochemical status, and vegetable and fruit consumption, and a discussion of the role of this evidence in making nutrition recommendations.

    More than 30 case-control and cohort studies were conducted over many years in various populations and indicated that people who eat more vegetables and fruit, foods rich in carotenoids, and carotenoids (bêta-carotene in particular), as well as those with higher blood bêta-carotene concentrations, have a lower risk of lung cancer than those who eat fewer such foods or have lower bêta-carotene concentrations.

    In contrast, the intervention results from large, controlled trials of bêta-carotene supplementation do not support the observed beneficial associations or a role for supplemental bêta-carotene in lung cancer prevention ; instead, they provide striking evidence for adverse effects (ie, excess lung cancer incidence and overall mortality) in smokers. (...)

    Mots-clés Pascal : Etude cas, Bétacarotène, Consommation alimentaire, Antioxydant, Epidémiologie, Recommandation alimentaire, Essai clinique, Tumeur maligne, Bronchopulmonaire, Prévention, Caroténoïde, Vitamine, Comportement alimentaire, Alimentation, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Homme

    Mots-clés Pascal anglais : Case study, Betacarotene, Food intake, Antioxidant, Epidemiology, Dietary allowance, Clinical trial, Malignant tumor, Bronchopulmonary, Prevention, Carotenoid, Vitamin, Feeding behavior, Feeding, Respiratory disease, Lung disease, Bronchus disease, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0387957

    Code Inist : 002B11A. Création : 22/03/2000.