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  1. Oestradiol and sex hormone-binding globulin in premenopausal and post-menopausal meat-eaters, vegetarians and vegans.

    Article - En anglais

    Endogenous oestradiol is strongly associated with breast cancer risk but its determinants are poorly understood.

    To test the hypothesis that vegetarians have lower plasma oestradiol and higher sex hormone-binding globulin (SHBG) than meat-eaters we assayed samples from 640 premenopausal women (153 meat-eaters, 382 vegetarians, 105 vegans) and 457 post-menopausal women (223 meat-eaters, 196 vegetarians, 38 vegans).

    Vegetarians and vegans had lower mean body mass indices (BMI) and lower plasma cholesterol concentrations than meat-eaters, but there were no statistically significant differences between meat-eaters, vegetarians and vegans in pre-or post-menopausal plasma concentrations of oestradiol or SHBG.

    Before adjusting for BMI there were small differences in the direction expected, with the vegetarians and vegans having higher SHBG and lower oestradiol (more noticeable amongst post-menopausal women) than the meat-eaters.

    These small differences were essentially eliminated by adjusting for BMI.

    Thus this study implies that the relatively low BMI of vegetarians and vegans does cause small changes in SHBG and in post-menopausal oestradiol, but that the composition of vegetarian diets may not have any additional effects on these hormones.

    Mots-clés Pascal : Tumeur maligne, Glande mammaire, Facteur risque, Estradiol, Préménopause, Postménopause, Protéine liaison hormone stéroïde sexuelle, Indice masse corporelle, Cholestérol, Régime alimentaire végétarien, Epidémiologie, Royaume Uni, Europe, Femelle, Homme, Glande mammaire pathologie, Oestrogène, Hormone ovarienne, Hormone stéroïde sexuelle, Lipide

    Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Risk factor, Estradiol, Premenopause, Postmenopause, Sex hormone binding protein, Body mass index, Cholesterol, Vegetarian diet, Epidemiology, United Kingdom, Europe, Female, Human, Mammary gland diseases, Estrogen, Ovarian hormone, Sex steroid hormone, Lipids

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0386769

    Code Inist : 002B20E02. Création : 22/03/2000.